LUGPA 2025 CME Enduring Program: Operationalizing the Science -Translating New Concepts into Clinical Practice-2025 CME Program Part 7

Video Transcription

Video Summary

Dr. Ryan Nelson demonstrated the use of the DaVinci SP robotic system for regionalizing radical prostatectomy, highlighting benefits like extraperitoneal access, reduced complications, improved visualization, and excellent postoperative outcomes such as minimal blood loss, fast recovery, and preserved erectile function. He emphasized a stepwise approach from “single port plus one” to single port alone, with detailed surgical techniques including trans-vesicle dissection and V-lock sutured anastomosis. Following this, Dr. Barata discussed the importance of genetic testing in advanced prostate cancer, differentiating germline (inherited) and somatic (tumor) testing. Testing identifies DNA repair mutations (e.g., BRCA1/2), which have prognostic and predictive implications, enabling use of targeted therapies like PARP inhibitors and immunotherapy for mismatch repair deficiencies. He stressed that many patients qualifying for testing are missed if relying on family history alone, advocating for broader, universal genetic testing. He also highlighted ongoing research into novel treatments and combination therapies to improve personalized care, urging the medical community to increase genetic testing rates for better outcomes.

Keywords

DaVinci SP robotic system

radical prostatectomy

extraperitoneal access

genetic testing

DNA repair mutations

targeted therapies