LUGPA 2026 Global Prostate Cancer Congress Enduring Program-Session 9

Video Transcription

Video Summary

The transcript captures a conference session urging urologists to more proactively manage androgen deprivation therapy (ADT) side effects, especially major adverse cardiovascular events (MACE), as treatment intensifies from doublet to triplet regimens. Speakers emphasize that “quadruplet therapy” should include systematic mitigation of ADT toxicities to keep patients alive, not just cancer-controlled.<br /><br />Advanced practice providers outline common ADT complications—fatigue, weight gain, muscle loss, osteoporosis, hot flashes, sexual dysfunction, mood/cognitive changes, and cardiometabolic disease—and stress exercise (aerobic plus resistance) as the most effective intervention for fatigue, sarcopenia, bone health, mood, and overall outcomes. Bone health measures include DEXA scans and calcium plus vitamin D. Hot flashes are addressed with medications such as venlafaxine, gabapentin, or medroxyprogesterone, plus lifestyle adjustments.<br /><br />A multidisciplinary guideline initiative, PC360, provides practical recommendations across cardiometabolic, bone, sexual, psychological, and lifestyle domains. Implementation is being tested via Medicare Chronic Care Management (CCM), using nurse coordinators to deliver monthly education, monitoring, referrals, and adherence support. Early data show gaps in DEXA/vitamin D adherence, falls, and hospitalizations, supporting ongoing surveillance and coordinated care.

Keywords

androgen deprivation therapy side effects

major adverse cardiovascular events MACE

triplet therapy intensification

exercise aerobic and resistance training

sarcopenia and muscle loss

bone health DEXA calcium vitamin D

hot flash management venlafaxine gabapentin

PC360 multidisciplinary guidelines

Medicare Chronic Care Management nurse coordination